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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
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Self-emulsifying Drug Delivery Systems: Concept to Applications, Regulatory Issues, Recent Patents, Current
Rajib Lochan Maharana1, Suryakanta Swain2, Santosh Kumar Mahapatra3
1Pharmacy, Biju Patnaik University of Technology (BPUT), Chhend Colony, Rourkela, 769004, Odisha, India.
Current Pharmaceutical Biotechnology
|June 24, 2024
Summary
Self-emulsifying drug delivery systems (SEDDS) enhance solubility and bioavailability for poorly soluble drugs. This review covers SEDDS advancements, formulation, characterization, and future opportunities for improved drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- A significant percentage of new pharmaceuticals exhibit poor water solubility, posing challenges for oral administration.
- Poor solubility leads to issues like dosage proportionality, high variability, and limited bioavailability, especially in the lungs.
Purpose of the Study:
- To summarize advances, components, variations, production techniques, characterization, limitations, and opportunities for Self-emulsifying drug delivery systems (SEDDS).
- To provide a current account of biopharmaceutical advancements in SEDDS, including Quality by Design (QbD) and regulatory aspects.
Main Methods:
- Review of existing literature on SEDDS.
- Analysis of formulation components, including surfactants, co-surfactants, and cosolvents.
- Exploration of production and characterization techniques for SEDDS.
Main Results:
- SEDDS formulations, containing lipophilic drugs, can form microemulsions and emulsions with minimal agitation.
- Effectiveness of various SEDDS formulations and techniques has been demonstrated for lipophilic drugs.
- The study highlights the application of QbD methodologies for optimizing drug formulations within SEDDS.
Conclusions:
- SEDDS offer a promising approach to overcome poor drug solubility and enhance bioavailability.
- Future directions include optimizing SEDDS composition, evaluation, diverse dosage forms, and solid-state conversion techniques.
- Addressing regulatory roadblocks is crucial for the progression of SEDDS technology.
Keywords:
Isotropic mixturesapplicationscharacterizationextrusion spheronizationquality by design.ternary phase diagramMore Related Videos
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