Related Experiment Video
Updated: Jun 23, 2025
09:08
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
5.4K
Systemic Capillary Leak Syndrome as a Paraneoplastic Syndrome
Bernardo Silva1, Vasco Gaspar1, Cláudia Alves1
1Internal Medicine, Hospital Distrital de Santarém, Santarém, PRT.
Cureus
|June 24, 2024
Summary
Systemic capillary leak syndrome (SCLS) is a rare condition. This case highlights SCLS as a paraneoplastic syndrome revealing an underlying large B-cell lymphoma, a type of non-Hodgkin lymphoma.
Area of Science:
- Oncology
- Hematology
- Immunology
Background:
- Systemic capillary leak syndrome (SCLS) is a rare disorder with diverse potential causes, including idiopathic, infections, autoimmune diseases, drugs, surgery, and cancer.
- While cancers can precipitate SCLS, its presentation as an initial symptom of non-Hodgkin lymphoma is exceptionally uncommon.
Observation:
- This report details a unique case where SCLS manifested as a paraneoplastic syndrome.
- The paraneoplastic SCLS served as the presenting sign, leading to the diagnosis of a significant underlying B-cell lymphoma.
Findings:
- The study identifies a specific instance of SCLS being the inaugural clinical manifestation of a large B-cell lymphoma.
- This finding underscores the potential for SCLS to be an early indicator of hematological malignancies, specifically non-Hodgkin lymphoma.
Implications:
- This case expands the understanding of SCLS etiology, emphasizing its role as a potential paraneoplastic phenomenon.
- It suggests the importance of considering hematological malignancies, particularly non-Hodgkin lymphoma, in the differential diagnosis of SCLS, especially when other causes are not apparent.
