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Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model
Published on: February 7, 2025
Osteogenesis Imperfecta Type II: The Lethal Newborn Form Diagnosed in the Postnatal Period
Hasnae Elhaddadi1, Anass Ayyad2, Sahar Messaoudi2
1Department of Pediatrics, University Hospital Mohammed VI, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, MAR.
Abstract:
Osteogenesis imperfecta (OI) is a rare inherited skeletal disease, characterized by bone fragility and low bone density. There are several types of OI, varying in severity from benign to severe. We report a case of type II OI, which is a lethal form according to the Sillence classification. At birth, the newborn presented immediate respiratory distress. Postnatal examination and bone radiography confirmed the diagnosis of OI type IIA. The genetic analysis was done along with genetic counseling. Death occurred on day nine of life due to respiratory failure secondary to pulmonary hypoplasia.
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