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Generation of Human Kidney Tubuloids from Tissue and Urine
Published on: April 16, 2021
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Progress and breakthroughs in human kidney organoid research
Qi Liu1, Liang Yue2, Jiu Deng3
1School of Biomedical Engineering, Dalian University of Technology, Dalian, 116024, China.
Biochemistry and Biophysics Reports
|June 24, 2024
Summary
Three-dimensional kidney organoids model renal development and function. Advances in bioengineering and bioinformatics enhance their accuracy for studying kidney disease mechanisms.
Area of Science:
- Biomedical Engineering
- Developmental Biology
- Regenerative Medicine
Background:
- Three-dimensional (3D) kidney organoids are advanced in vitro models that mimic mammalian kidney organogenesis.
- Established protocols exist for cultivating kidney organoids from induced pluripotent stem cells (iPSCs) and adult stem cells (ASCs).
Purpose of the Study:
- To review the evolution of kidney organoid generation methods.
- To highlight recent advancements in bioengineering and bioinformatics for improved kidney organoid models.
- To summarize applications of kidney organoids in renal disease research.
Main Methods:
- Review of scientific literature on kidney organoid development and applications.
- Analysis of advancements in bioengineering and bioinformatics integration.
- Synthesis of current knowledge on kidney organoid utility in disease modeling.
Main Results:
- Kidney organoid technology has evolved significantly, offering improved recapitulation of renal morphology and function.
- Integration of bioengineering and bioinformatics enhances developmental accuracy and enables high-throughput studies.
- Kidney organoids serve as valuable tools for mechanistic research and disease exploration.
Conclusions:
- Kidney organoids represent a powerful tool for understanding kidney development and disease.
- Continued technological integration promises more sophisticated models for renal research.
- Applications in exploring kidney diseases are expanding, offering new avenues for therapeutic development.
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