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Updated: Jun 23, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
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Telomere-related DNA damage response pathways in cancer therapy: prospective targets

Liting Gu1, Mingdi Liu1, Yuning Zhang1

  • 1Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, Jilin, China.

Frontiers in Pharmacology
|June 24, 2024
PubMed

Insights

Genomic DNA integrity relies on DNA damage response (DDR) and telomere protection. Their interaction is crucial for aging, cancer, and tumor treatment efficacy, though more research is needed.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Cellular life depends on maintaining genomic DNA structural integrity.
  • Two key mechanisms, DNA damage response (DDR) and telomere protection, are vital for this maintenance.
  • Abnormalities in telomeres and DDR are linked to aging and cancer, indicating a reciprocal regulatory relationship.

Purpose of the Study:

  • To review research progress on the interaction between telomeres and cellular DNA damage repair pathways.
  • To highlight the importance of understanding the crosstalk between telomere damage and DDR.
  • To explore the implications for improving tumor treatment efficacy.

Main Methods:

  • Literature review of scientific research.
  • Analysis of studies on telomere biology and DNA damage repair.
  • Synthesis of findings on the regulatory interplay between telomeres and DDR.

Main Results:

  • Telomeres and cellular DDR are reciprocally regulated.
  • Research indicates a significant crosstalk between telomere damage and DDR pathways.
  • Existing drug treatments for DDR are available.

Conclusions:

  • The interaction between telomeres and DDR is critical for cellular health.
  • Understanding this crosstalk is essential for advancing cancer therapy.
  • Further research is required to fully elucidate and confirm the therapeutic potential of targeting this interaction.
Keywords:
DNA damage responsealternative lengthening of telomerescancertelomerase inhibitortelomere

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