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Non-diabetic elderly populations: the MHR as a protective factor against bone abnormalities
Xiang Li1, Manli Yan2, Jiali Ji2
1Department of Orthopedic, Guangdong, Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China.
Frontiers in Endocrinology
|June 24, 2024
Summary
The monocyte to high-density lipoprotein ratio (MHR) is a protective factor against bone abnormalities in non-diabetic elderly individuals. Higher MHR levels were observed in those with normal bone density, suggesting its potential role in preventing osteoporosis.
Area of Science:
- Gerontology
- Biochemistry
- Public Health
Background:
- Osteoporosis is a significant health concern in China's elderly population.
- The monocyte to high-density lipoprotein ratio (MHR) is a potential marker for inflammation and oxidative stress in type 2 diabetes mellitus (T2DM)-related osteoporosis.
- The utility of MHR in non-diabetic elderly individuals with osteoporosis is not well-established.
Purpose of the Study:
- To investigate the association between MHR and osteoporosis in a non-diabetic elderly population.
- To determine if MHR can serve as a reliable indicator of bone health in this demographic.
Main Methods:
- Retrospective analysis of clinical data from 240 non-diabetic elderly subjects (115 osteoporosis, 125 normal bone density).
- Statistical analysis including binary logistic regression and Receiver Operating Characteristic (ROC) curve analysis.
- Correlation analysis between MHR and bone mineral density (BMD) and stress ratios.
Main Results:
- Statistically significant differences were found in age, MHR, and various blood markers between the osteoporosis and normal bone groups.
- Age was identified as an independent risk factor, while MHR emerged as an independent protective factor for bone abnormality.
- MHR showed a positive correlation with lumbar and hip BMD and negative associations with femoral stress ratios.
Conclusions:
- MHR acts as a protective factor against bone abnormalities in the non-diabetic elderly population.
- MHR levels were significantly higher in individuals with normal bone density compared to those with osteoporosis.
- MHR may be a valuable biomarker for assessing osteoporosis risk in non-diabetic elderly individuals.
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