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Targeting CD300ld to normalize the tumor microenvironment: an emerging insight in cancer immunotherapy
Lin-Zhu Zhang1,2, Xu He3, Hai-Dong Zhu1,2
1Department of Radiology Center of Interventional Radiology and Vascular Surgery Medical School Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging and Interventional Radiology (Southeast University) Zhongda Hospital Southeast University Nanjing China.
Abstract:
In a recent Nature elegant study, Wang et al. identified CD300ld, a novel functionally highly conserved tumor immunosuppressive receptor, highly expressed specifically on polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), as well as a key receptor in the regulation of recruitment and immunosuppressive function of PMN-MDSCs. Targeting CD300ld could remodel the tumor immune microenvironment, resulting in a broad-spectrum anti-tumor effect.
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