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A decade with anomic primary progressive aphasia.

Shoko Ota1, Kazuo Kakinuma1, Wataru Narita2

  • 1Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.

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Summary

This case study follows a patient with primary progressive aphasia (PPA) who experienced pure anomic aphasia for nine years. The findings suggest a slowly progressive, late-onset anomic PPA variant distinct from other PPA types.

Keywords:
Anomic aphasiaClinical courseLate-onsetPrimary progressive aphasia

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Area of Science:

  • Neurology
  • Linguistics
  • Gerontology

Background:

  • Primary progressive aphasia (PPA) is a neurodegenerative disorder affecting language.
  • Anomic PPA, characterized by word-finding difficulties, has unclear diagnostic criteria regarding its progression and relation to other PPA variants.
  • Longitudinal studies are crucial for understanding the distinctiveness of anomic PPA.

Observation:

  • A 10-year clinical course of a right-handed male patient with late-onset anomic PPA, starting at age 73.
  • Initial presentation at age 77 showed pure anomic aphasia with preserved episodic memory and visuospatial functions.
  • Magnetic resonance imaging (MRI) revealed left temporal lobe atrophy.

Findings:

  • The patient maintained pure anomic aphasia for nine years.
  • At age 83, mild impairments in word comprehension and semantic memory emerged alongside persistent anomia.
  • Progressive atrophy in bilateral anterior temporal lobes, predominantly left-sided, was observed via MRI.

Implications:

  • This case supports the existence of a slowly progressive, late-onset anomic PPA.
  • This variant may be distinguishable from early stages of semantic or logopenic PPA.
  • Further longitudinal research is warranted to fully characterize anomic PPA subtypes.