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The association between declining lung function and stroke risk: insights from an observational study and Mendelian
Jiadong Wang1,2, Junjie Lin3, Yujie Zheng1
1Hangzhou Third People's Hospital, Hangzhou, China.
Frontiers in Neurology
|June 24, 2024
Summary
Reduced lung function, indicated by lower peak expiratory flow (PEF), is linked to increased stroke risk. Monitoring PEF may aid in primary stroke prevention strategies globally.
Area of Science:
- Pulmonary Medicine
- Neurology
- Epidemiology
Background:
- Stroke is a leading global cause of mortality and disability, disproportionately affecting low- and middle-income countries.
- Decreased lung function is an identified risk factor for stroke, yet research on this association, particularly using large population samples, remains limited.
- This study investigates the relationship between lung function and stroke incidence.
Purpose of the Study:
- To explore the association between lung function, specifically peak expiratory flow (PEF), and the incidence of stroke.
- To assess both cross-sectional and longitudinal relationships between PEF and stroke risk.
- To investigate the potential causal link between PEF and stroke using genetic data.
Main Methods:
- Analysis of data from a U.S. national cross-sectional study (n=13,371) and a Chinese national cohort study (n=11,192).
- Application of multivariate logistic regression and Cox proportional hazards regression to evaluate associations.
- Utilized Mendelian randomization analysis with publicly available GWAS data from a European population to explore causality.
Main Results:
- Cross-sectional analysis indicated an association between reduced PEF and increased stroke risk.
- Longitudinal analysis showed a 19-21.4% decreased risk of stroke incidence in higher PEF tertile groups compared to the lowest.
- Mendelian randomization analysis revealed that higher PEF levels are significantly associated with a reduced risk of stroke.
Conclusions:
- Decreased lung function, as measured by PEF, is a significant risk factor for stroke.
- Peak expiratory flow serves as a simple, accurate indicator for monitoring lung function.
- PEF monitoring can be a valuable tool for primary stroke prevention in community and patient settings.
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