Concurrent left ventricular and left anterior coronary artery thrombus: is COVID-19 an innocent bystander?

Vincenzo Somma1, Anthony Brennan2, Francis Ha2

  • 1Internal Medicine Trainee.

Insights

This study details a case of myocardial infarction (heart attack) linked to COVID-19. Angiography revealed significant blood clots despite minimal coronary artery blockages.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Vascular Medicine

Background:

  • COVID-19 is associated with an increased risk of thrombotic events.
  • Myocardial infarction can occur in the context of COVID-19 infection.
  • The underlying mechanisms linking COVID-19 to cardiovascular events are still being investigated.

Purpose of the Study:

  • To present the angiographic findings in a patient with myocardial infarction and COVID-19.
  • To highlight the presence of a heavy thrombus burden despite minimal obstructive coronary artery disease.

Main Methods:

  • Case report presentation.
  • Review of angiographic findings.
  • Clinical correlation of COVID-19 infection and cardiac event.

Main Results:

  • Angiography demonstrated a significant thrombus burden in the coronary arteries.
  • Obstructive coronary artery disease was noted to be minor.
  • The patient experienced myocardial infarction in the setting of COVID-19.

Conclusions:

  • COVID-19 can precipitate acute coronary syndromes with substantial thrombus formation.
  • Thrombus burden in COVID-19-associated myocardial infarction may not correlate with the degree of underlying coronary atherosclerosis.
  • Further research is needed to elucidate the prothrombotic mechanisms of COVID-19 affecting coronary arteries.

Related Concept Videos

Coronary Circulation01:21

Coronary Circulation

The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
2.6K
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.3K
Physiology of the Heart: The Cardiac Cycle01:18

Physiology of the Heart: The Cardiac Cycle

The cardiac cycle describes the events from one heartbeat to the next. It includes three main phases: diastole, atrial systole, and ventricular systole, all driven by changes in chamber pressures and the function of heart valves.
Diastole: The Relaxation Phase
During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...
2.4K
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K