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Updated: May 5, 2026

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Rapidly Progressive Apical Hypertrophic Cardiomyopathy: Not Everything is What It Seems

Ahmed K Mahmoud1, Juan M Farina1, Kamal Awad1

  • 1Mayo Clinic, Phoenix, Arizona, US.

Methodist Debakey Cardiovascular Journal
|June 24, 2024
PubMed

Insights

Apical hypertrophic cardiomyopathy (HCM) is a rare heart condition. This case shows its rapid development and diagnostic challenges in a patient with hypertension and a kidney transplant.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Genetics

Background:

  • Apical hypertrophic cardiomyopathy (HCM) is an uncommon form of HCM.
  • It presents unique diagnostic challenges compared to other HCM variants.

Observation:

  • A 43-year-old female with hypertension and a history of kidney transplantation experienced syncope and dyspnea.
  • Electrocardiogram revealed diffuse giant T-wave inversions.
  • Cardiac MRI confirmed HCM with circumferential apical thickening.

Findings:

  • The patient's presentation and imaging findings are consistent with apical HCM.
  • The case illustrates the potential for rapid progression of this condition.

Implications:

  • This case underscores the importance of recognizing the distinct features of apical HCM.
  • Advanced imaging techniques like cardiac MRI are crucial for accurate diagnosis.
  • Understanding rapid development is key for timely intervention in apical HCM.

Keywords:
cardiomyopathydyspneaelectrocardiographyphysical exertionsyncope

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