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Updated: Jun 23, 2025
Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
Published on: June 14, 2017
Serum proteomics study on cognitive impairment after cardiac valve replacement surgery: a prospective observational
Huanhuan Ma1,2, Yiyong Wei3, Wei Chen4
1Department of Anesthesiology, Medical College of Soochow University, Soochow, Jiangsu Province, China.
Objective:
The incidence of perioperative neurocognitive disorders (PND) is high, especially after cardiac surgeries, and the underlying mechanisms remain elusive. Here, we conducted a prospective observational study to observe serum proteomics differences in PND patients after cardiac valve replacement surgery.
Methods:
Two hundred and twenty-six patients who underwent cardiac valve surgery were included. They were categorized based on scoring into non-PND group (group non-P) and PND group (group P'). The risk factors associated with PND were analyzed. These patients were further divided into group C and group P by propensity score matching (PSM) to investigate the serum proteome related to the PND by serum proteomics.
Results:
The postoperative 6-week incidence of PND was 16.8%. Risk factors for PND include age, chronic illness, sufentanil dosage, and time of cardiopulmonary bypass (CPB). Proteomics identified 31 down-regulated proteins and six up-regulated proteins. Finally, GSTO1, IDH1, CAT, and PFN1 were found to be associated with PND.
Conclusion:
The occurrence of PND can impact some oxidative stress proteins. This study provided data for future studies about PND to general anaesthesia and surgeries.
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