Early life manganese exposure and reported attention-related behaviors in Italian adolescents
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View abstract on PubMed
Summary
This summary is machine-generated.Manganese (Mn) exposure during early life may benefit attention in adolescents. Prenatal and postnatal Mn exposure showed protective associations with inattention, but childhood exposure did not.
Area Of Science
- Neuroscience
- Environmental Health
- Developmental Pediatrics
Background
- Manganese (Mn) is an essential nutrient and neurotoxicant.
- Neurodevelopmental effects of Mn exposure may vary by timing.
- Limited research quantitatively compares Mn's impact across different exposure periods.
Purpose Of The Study
- To quantitatively assess the association between manganese (Mn) exposure during distinct early life periods and attention-related behaviors in adolescence.
- To compare the neurodevelopmental impact of Mn exposure across prenatal, postnatal, and childhood periods.
Main Methods
- Utilized data from 125 Italian adolescents (10-14 years).
- Quantified manganese (Mn) in deciduous teeth using laser ablation-inductively coupled plasma-mass spectrometry to represent prenatal, postnatal, and childhood exposure.
- Assessed attention-related behaviors using Conners Behavior Rating Scales and analyzed associations with multivariable linear regression and multiple informant models.
Main Results
- A doubling in prenatal tooth Mn levels correlated with lower teacher-reported inattention scores (5.3% decrease).
- A doubling in postnatal tooth Mn levels correlated with lower parent-reported inattention (4.5% decrease) and attention deficit/hyperactivity disorder index scores (4.6% decrease).
- Manganese (Mn) exposure during childhood was not associated with beneficial effects on attention-related behaviors.
Conclusions
- Prenatal and postnatal manganese (Mn) exposure demonstrate protective associations with attention-related behaviors in adolescence.
- The timing of manganese (Mn) exposure is critical, with benefits observed in early life but not in childhood.
- Findings suggest a potential beneficial role of manganese (Mn) in neurodevelopment during specific early life windows.
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