Impact of butorphanol versus sufentanil on postoperative cognition and inflammation in elderly: a pilot study
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View abstract on PubMed
Summary
This summary is machine-generated.Butorphanol significantly reduced early post-operative cognitive dysfunction (POCD) and systemic inflammation in older surgical patients compared to sufentanil. This suggests butorphanol may be a preferred anesthetic agent for this population.
Area Of Science
- Anesthesiology
- Geriatric Medicine
- Neuroscience
Background
- Post-operative cognitive dysfunction (POCD) is a significant concern in older surgical patients.
- Systemic inflammation plays a role in the development of POCD.
- Opioid selection during anesthesia may influence perioperative outcomes.
Purpose Of The Study
- To compare the efficacy of butorphanol versus sufentanil in preventing early POCD in elderly surgical patients.
- To evaluate the impact of butorphanol and sufentanil on systemic inflammatory markers.
- To determine if butorphanol offers an advantage over sufentanil in managing perioperative inflammation and cognitive function.
Main Methods
- A randomized controlled trial involving 114 patients aged 65 years and above undergoing general anesthesia.
- Patients were randomized to receive either butorphanol (40 μg/kg) or sufentanil (0.4 μg/kg) during anesthesia induction.
- Cognitive function was assessed using MMSE and MoCA scales; POCD was defined using Z-scores. Inflammatory markers (TNF-α, IL-1β, IL-10) were measured via ELISA.
Main Results
- Butorphanol significantly reduced the incidence of POCD on postoperative days 1 and 3 compared to sufentanil (p < 0.05).
- Patients receiving butorphanol exhibited lower levels of TNF-α and IL-1β post-surgery (p < 0.05).
- Butorphanol administration was associated with significantly higher levels of IL-10 compared to sufentanil (p < 0.05).
Conclusions
- Butorphanol administration during anesthesia induction is associated with a reduced incidence of early POCD in older surgical patients.
- The anti-inflammatory effects of butorphanol may contribute to its neuroprotective benefits in this population.
- Butorphanol shows promise as a superior anesthetic agent for mitigating POCD and systemic inflammation in elderly patients.
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