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Possible relationship between respiratory diseases and urinary concentrations of polycyclic aromatic hydrocarbon

Veronika Gomersall1, Katerina Ciglova1, Hana Barosova2

  • 1University of Chemistry and Technology, Faculty of Food and Biochemical Technology, Department of Food Analysis and Nutrition, Prague, Czech Republic.

Journal of Applied Biomedicine
|June 24, 2024
PubMed

Insights

Children in Most, Czech Republic, showed higher urinary polycyclic aromatic hydrocarbon (PAH) metabolite levels and increased respiratory illnesses, including influenza. This highlights environmental PAH exposure risks for pediatric respiratory health.

Area of Science:

  • Environmental Health
  • Pediatric Toxicology
  • Biomonitoring

Background:

  • Polycyclic Aromatic Hydrocarbons (PAHs) are environmental pollutants with potential health impacts.
  • Monohydroxylated metabolites (OH-PAHs) in urine serve as biomarkers for PAH exposure.
  • Previous studies suggested distinct patterns in the Most population, a historically contaminated area.

Purpose of the Study:

  • To investigate the relationship between urinary OH-PAH levels and respiratory disease prevalence in 2-year-old children.
  • To compare exposure biomarkers and health outcomes between children in České Budějovice and Most, Czech Republic.
  • To assess the impact of environmental PAH exposure on pediatric respiratory health.

Main Methods:

  • Analysis of 248 urine samples for 11 OH-PAHs using liquid-liquid extraction and ultra-high performance liquid chromatography-tandem mass spectrometry.
  • Assessment of respiratory disease incidence via pediatrician-administered questionnaires.
  • Comparative study design between a control location (České Budějovice) and a contaminated site (Most).

Main Results:

  • Elevated urinary OH-PAH concentrations were found in children from Most compared to České Budějovice.
  • A statistically significant association was observed between higher OH-PAH levels and increased respiratory disease incidence in Most children.
  • Higher incidence of influenza was also noted in children from Most.

Conclusions:

  • Environmental PAH exposure, indicated by elevated urinary OH-PAHs, is associated with an increased risk of respiratory diseases in young children.
  • Findings underscore the impact of PAH exposure on pediatric respiratory health in historically contaminated areas.
  • Further research is warranted to elucidate long-term health effects and inform public health strategies.

Keywords:
2-year-old toddlersInfluenzaMonohydroxylated PAH metabolitesPolycyclic aromatic hydrocarbonsRespiratory diseasesUrine

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