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Related Experiment Video

Updated: May 1, 2026

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

Prostatic Utricle Cysts as a Potential Pitfall in PSMA PET/CT Interpretation.

Bradley J Girod¹, Nghi C Nguyen

¹From the Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX.

Clinical Nuclear Medicine

|June 24, 2024

Summary

This summary is machine-generated.

Prostatic utricle cysts can mimic prostate cancer recurrence on PSMA PET scans. Careful interpretation is crucial to avoid misdiagnosis and ensure appropriate treatment for prostate cancer patients.

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Area of Science:

Oncology
Nuclear Medicine
Radiotherapy

Background:

Prostate cancer management involves radiotherapy and monitoring using prostate-specific membrane antigen (PSMA) Positron Emission Tomography/Computed Tomography (PET/CT).
Biochemical recurrence after initial treatment necessitates accurate staging and localization of disease.

Observation:

A 60-year-old man with T2aN0M0 prostate cancer, treated with intensity-modulated radiotherapy, presented with biochemical recurrence 6 years post-treatment.
68Ga-PSMA-11 PET/CT showed focal radioactivity in the prostate's posterior midline, initially concerning for recurrence.
Subsequent MRI identified the focus as a prostatic utricle cyst, a finding also noted on a prior 18F-piflufolastat PET/CT with negative biopsy results.

Findings:

Prostatic utricle cysts can exhibit PSMA avidity, potentially leading to misinterpretation as recurrent prostate cancer on PSMA PET/CT scans.
Despite the PSMA-avid focus, the patient's negative biopsy results indicated the absence of malignancy at that site.

Implications:

This case underscores the importance of considering benign prostatic anomalies, such as utricle cysts, in the differential diagnosis of PSMA-avid lesions in prostate cancer patients.
Accurate interpretation of PSMA PET/CT is vital to prevent misdiagnosis and guide appropriate treatment strategies, avoiding unnecessary interventions.
Integration of imaging modalities like MRI with PSMA PET/CT can improve diagnostic accuracy in cases of suspected prostate cancer recurrence.