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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Oncology And Carcinogenesis
Predictive And Prognostic Markers
Prognostic Significance Of Micronest In Cancer Stroma In Resected Lung Squamous Cell Carcinoma.

Home
Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
Prognostic Significance Of Micronest In Cancer Stroma In Resected Lung Squamous Cell Carcinoma.

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Prognostic significance of micronest in cancer stroma in resected lung squamous cell carcinoma.

Yasunori Kaminuma¹, Tokiko Nakai², Keiju Aokage³

¹Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Chiba, Japan; Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan; Course of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Human Pathology

|June 24, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Micronests in cancer stroma (MICS) are a significant prognostic factor in lung squamous cell carcinoma. Their presence indicates poorer overall survival and recurrence-free survival, highlighting their clinical importance.

Keywords:

Cancer stroma Lung cancer Micronest Squamous cell carcinoma

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Area of Science:

Oncology
Pathology
Cancer Research

Background:

Tumor budding is a known prognostic factor in non-small cell lung cancer.
Micronests in cancer stroma (MICS) are larger than tumor buds, but their clinical significance is not well understood.

Purpose of the Study:

To investigate the clinicopathological significance of MICS in lung squamous cell carcinoma (LSqCC).
To evaluate MICS as a prognostic factor for patient survival and recurrence.

Main Methods:

Retrospective analysis of 198 LSqCC patients.
Defined MICS based on size, cell count, and distance from the main tumor.
Utilized immunohistochemistry (IHC) to assess MICS cell characteristics.

Main Results:

MICS were present in 28.8% of patients.
MICS-positive patients had significantly shorter overall survival (OS) and recurrence-free survival (RFS).
MICS presence was an independent poor prognostic factor (HR 3.54 for OS, HR 4.99 for RFS).
MICS cells showed decreased E-cadherin and GLUT-1 expression compared to non-MICS lesions.

Conclusions:

Micronests in cancer stroma (MICS) represent a distinct morphological feature with significant biological and prognostic implications in LSqCC.
MICS are associated with reduced patient survival and increased recurrence risk.
Further research into the biological mechanisms underlying MICS is warranted.