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Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Theoretical Approaches to Psychological Disorder01:29

Theoretical Approaches to Psychological Disorder

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The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Schizophrenia01:17

Schizophrenia

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Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
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Related Experiment Video

Updated: Jun 23, 2025

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Functional phenotypes in schizophrenia spectrum disorders: defining the constructs and identifying biopsychosocial

Sunny X Tang1,2,3, Katrin Hänsel4, Lindsay D Oliver5

  • 1Division of Psychiatry Research, Feinstein Institutes for Medical Research, Northwell Health, New Hyde Park, NY, USA. Stang3@northwell.edu.

Schizophrenia (Heidelberg, Germany)
|June 24, 2024
PubMed
Summary

Three distinct functional profiles in schizophrenia spectrum disorders (SSD) were identified. Key factors influencing these profiles include avolition, anhedonia, and hippocampal volume, suggesting tailored interventions for improved quality of life.

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Area of Science:

  • Psychiatry
  • Neuroscience
  • Clinical Psychology

Background:

  • Functional impairments significantly impact quality of life in schizophrenia spectrum disorders (SSD).
  • Understanding distinct functional profiles is crucial for effective treatment and recovery.

Purpose of the Study:

  • To define and replicate main functional phenotypes in SSD using data-driven methods.
  • To identify key biopsychosocial correlates associated with these functional phenotypes.

Main Methods:

  • Clustering analysis was performed on independent datasets (N=282, N=317) to identify functional phenotypes.
  • Latent discriminant analyses and regularized regressions identified key predictors from sociodemographic, psychological, clinical, cognitive, and brain measures.

Main Results:

  • Three replicable functional phenotypes were identified: poor functioning, impaired role functioning with preserved independent/social functioning, and good overall functioning.
  • Key correlates included avolition, anhedonia, left hippocampal volume, emotional intelligence, and subjective social experience.

Conclusions:

  • Recovery in SSD may not be uniform across all functional domains.
  • Avolition and anhedonia play distinct roles in different functional areas, highlighting the need for targeted interventions.