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Carbohydrates are an essential part of the diet in humans and animals. Grains, fruits, and vegetables are natural sources of carbohydrates that provide energy to the body, particularly through glucose, a simple sugar that is a component of starch and an ingredient in many staple foods. The stoichiometric formula (CH2O)n, where n is the number of carbons in the molecule represents carbohydrates. In other words, the ratio of carbon to hydrogen to oxygen is 1:2:1 in carbohydrate molecules. This...
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Carbohydrates, proteins, and fats are the primary macronutrients in the human diet. However, carbohydrates are the most favored source of energy in the body. They can be found in a wide variety of foods, including whole grains, fruit, and vegetables, in various forms, such as sugars, starch, and dietary fiber. Based on their structure, carbohydrates are classified into three main classes— monosaccharides, disaccharides, and polysaccharides. The body's cells can only utilize simple...
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Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
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Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
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Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
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Carbohydrate Structure Database: current state and recent developments.

Philip Toukach1,2

  • 1N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia. netbox@toukach.ru.

Analytical and Bioanalytical Chemistry
|June 24, 2024
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Summary
This summary is machine-generated.

The Carbohydrate Structure Database (CSDB) now offers comprehensive glycan data, including microbial glycans. New tools enhance glycoinformatic analysis, aiding researchers in carbohydrate structure elucidation.

Keywords:
CSDBCarbohydrate NMRCarbohydrate Structure DatabaseGlycoinformatics platform

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Area of Science:

  • Glycomics and Bioinformatics
  • Carbohydrate Chemistry and Structural Biology

Background:

  • The Carbohydrate Structure Database (CSDB) serves as a vital curated repository and glycoinformatic platform for glycan data.
  • Continuous development is essential to expand its utility and coverage for the scientific community.

Purpose of the Study:

  • To review recent advancements and new components integrated into the CSDB.
  • To highlight improvements in data coverage and the introduction of novel analytical and predictive tools.

Main Methods:

  • Database curation and expansion, focusing on microbial glycans.
  • Development and integration of new computational modules, including those for glycosyltransferases and saccharide conformations.
  • Implementation of user-friendly online tools such as a glycan builder, 3D modeler, and NMR simulator.

Main Results:

  • Achieved near-complete coverage of glycans originating from microorganisms.
  • Launched specialized modules for studying glycosyltransferases and predicting saccharide conformations.
  • Introduced an online glycan builder, 3D modeler, NMR simulator, and an NMR-based structure predictor.

Conclusions:

  • The CSDB has significantly enhanced its capabilities as a glycoinformatic platform.
  • Recent updates provide researchers with powerful tools for glycan analysis, structure prediction, and data visualization, particularly for microbial glycans.