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Abnormal cerebral blood flow in children with developmental stuttering
Wanqing Liu1,2, Dan Ma2,3, Chuanlong Cao4
1Department of Radiology, West China Second University Hospital, Sichuan University, Chengdu, China.
Pediatric Research
|June 24, 2024
Summary
Children who stutter show altered cerebral blood flow (CBF) in specific brain regions. Decreased CBF in the cerebellum and occipital gyrus, and increased CBF in the frontal gyrus, may help identify stuttering early.
Area of Science:
- Neuroimaging
- Developmental Neuroscience
- Speech and Language Disorders
Background:
- Stuttering affects 5% of children, with unclear neurological underpinnings.
- Identifying neuroimaging biomarkers is crucial for early detection and intervention.
- Resting-state cerebral blood flow (CBF) is a potential biomarker for developmental stuttering.
Purpose of the Study:
- To investigate differences in resting-state CBF between children with developmental stuttering and healthy controls.
- To identify potential neuroimaging biomarkers for stuttering.
- To explore the correlation between CBF abnormalities and stuttering severity.
Main Methods:
- Utilized pulsed arterial spin labelling magnetic resonance imaging to quantify CBF.
- Compared normalized CBF in 35 children with developmental stuttering and 27 healthy controls.
- Evaluated correlations between abnormal CBF and clinical indicators of stuttering.
Main Results:
- Children who stutter exhibited decreased normalized CBF in the cerebellum (lobule VI) and occipital gyrus (superior).
- Increased normalized CBF was observed in the frontal gyrus (medial superior, rectus, dorsolateral superior) in the stuttering group.
- Abnormal CBF in the left cerebellum lobule VI and left superior occipital gyrus correlated positively with stuttering severity.
Conclusions:
- Children who stutter display distinct patterns of altered CBF, with reductions in the cerebellum/occipital regions and increases in the frontal regions.
- Decreased CBF in the left cerebellum lobule VI and left superior occipital gyrus is associated with more severe stuttering.
- CBF alterations may serve as novel neuroimaging biomarkers for early detection and understanding of developmental stuttering.
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