Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clearance from the respiratory tract.

R B Schlesinger

    Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
    |June 1, 1985
    PubMed
    Summary

    Changes in how the body clears insoluble particles indicate responses to inhaled materials. This review covers clearance mechanisms, the importance of altered clearance, and assessment methods.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Three-dimensional computational fluid dynamics simulations of particle deposition in the tracheobronchial tree.

    Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2006
    Same author

    The health relevance of ambient particulate matter characteristics: coherence of toxicological and epidemiological inferences.

    Inhalation toxicology·2006
    Same author

    Ozone-induced modulation of cell-mediated immune responses in the lungs.

    Toxicology and applied pharmacology·2001
    Same author

    Clearance and translocation of aluminum oxide (alumina) from the lungs.

    Inhalation toxicology·2000
    Same author

    Toxicological bases for the setting of health-related air pollution standards.

    Annual review of public health·2000
    Same author

    Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations.

    Toxicological sciences : an official journal of the Society of Toxicology·2000

    Area of Science:

    • Toxicology
    • Pulmonary Medicine
    • Environmental Health

    Background:

    • Inhaled particles can impact lung health.
    • Particle clearance is a key defense mechanism.
    • Altered clearance signifies exposure effects.

    Purpose of the Study:

    • To review lung particle clearance mechanisms.
    • To highlight the significance of clearance changes.
    • To discuss methods for assessing particle clearance.

    Main Methods:

    • Literature review of particle clearance studies.
    • Analysis of clearance mechanisms (e.g., macrophage-mediated, mucociliary).
    • Examination of methods to quantify particle clearance.

    Main Results:

    • Clearance alterations are sensitive biomarkers of inhaled substance exposure.
    • Understanding clearance is crucial for risk assessment.
    • Various techniques exist to measure clearance rates.

    Conclusions:

    • Particle clearance is a vital indicator of lung response to inhaled materials.
    • Assessing clearance changes aids in evaluating exposure risks.
    • Further research into clearance mechanisms is warranted.

    Related Experiment Videos