Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Doxycycline bioavailability in capsules].

L N Berezovskaia, V G Koroleva, E K Granatova

    Antibiotiki
    |November 1, 1979
    PubMed
    Summary

    Soviet doxycycline capsules demonstrated rapid absorption and good bioavailability, comparable to US-manufactured versions. Solubility tests effectively predicted antibiotic availability in vitro.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Application of combined antibiotics in scarlet fever; experimental and clinical investigations].

    Antibiotiki·2014
    Same author

    [Antiviral activity of the antibiotic virusin 1609].

    Antibiotiki·2014
    Same author

    [Effect of antibiotic virusin 1609 on vaccinia virus and Taylor's virus].

    Antibiotiki·2014
    Same author

    [Method of primary selection of anti-viral antibiotics on chick embryos infected with influenza virus].

    Antibiotiki·2014
    Same author

    [Characteristics of pharmacokinetics of liposome-incorporated rifampicin in rats after intratracheal administration].

    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]·1992
    Same author

    [Obtaining liposomal preparations of various biologically active substances by the method of detergent flow analysis].

    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]·1992

    Area of Science:

    • Pharmacology
    • Pharmaceutical Sciences

    Background:

    • Doxycycline is a broad-spectrum antibiotic.
    • Assessing the bioavailability of generic medications is crucial for therapeutic equivalence.

    Purpose of the Study:

    • To evaluate the in vitro and in vivo performance of Soviet-manufactured doxycycline capsules.
    • To compare the bioavailability of Soviet doxycycline with US-manufactured doxycycline products.

    Main Methods:

    • In vitro studies: disintegration and solubility tests of doxycycline capsules.
    • In vivo studies: pharmacokinetic analysis in 25 human patients.
    • Comparative analysis with published data on US doxycycline formulations.

    Main Results:

    • Soviet doxycycline capsules exhibited rapid absorption in patients.
    • In vitro solubility correlated with in vivo antibiotic availability.
    • Bioavailability was comparable to that of US-marketed doxycycline capsules.

    Conclusions:

    • Soviet doxycycline capsules offer rapid absorption and acceptable bioavailability.
    • The solubility test serves as a reliable indicator for predicting doxycycline availability.
    • The study supports the therapeutic equivalence of Soviet doxycycline capsules to US counterparts.

    Related Experiment Videos