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Updated: Jun 23, 2025

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Electrocardiographic findings in patients with sickle cell disease: A protocol for systematic review and

Alireza Sadeghi1, Ehsan Taherifard2, Hamed Movahed2

  • 1Student Research Committee Shiraz University of Medical Sciences Shiraz Iran.

Health Science Reports
|June 25, 2024
PubMed

Insights

Electrocardiogram (ECG) abnormalities are common in sickle cell disease (SCD). This review identifies factors linked to these cardiac findings, guiding better patient management and screening for cardiovascular risks.

Area of Science:

  • Cardiology
  • Hematology
  • Public Health

Background:

  • Cardiovascular complications are a major concern in sickle cell disease (SCD) management.
  • Electrocardiography (ECG) is crucial for diagnosing cardiac issues in SCD patients.
  • High rates of critical ECG findings necessitate proactive cardiac screening in SCD.

Purpose of the Study:

  • To systematically review literature on factors associated with ECG abnormalities in SCD patients.
  • Identify sociodemographic, clinical, and paraclinical predictors of cardiac findings in SCD.
  • Inform improved cardiac screening and management strategies for SCD.

Main Methods:

  • Comprehensive literature search across major databases (PubMed, Embase, Scopus, Web of Science, Google Scholar).
  • Inclusion of original articles reporting associations between variables and ECG findings in SCD.
  • Quantitative analysis using random-effect model with subgroup analyses by SCD status, hemoglobinopathy type, and age.

Main Results:

  • This section is to be populated upon study completion.

Conclusions:

  • This section is to be populated upon study completion.
Abstract

Keywords:
electrocardiographymeta‐analysissickle cell diseasesystematic review

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