Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

41
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
41
Spermatogenesis01:41

Spermatogenesis

102.4K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.4K
Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

2.4K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of Age-Associated Circulating Proteins and Lipids in 3800 Comorbidity-Enriched Older Adults from Japan-Based Cohorts Using Olink Assays and MRM Mass Spectrometry.

Journal of proteome research·2026
Same author

Acute Cardiac Tamponade Following Enfortumab Vedotin Initiation in Metastatic Urothelial Carcinoma: Successful Rescue by Pericardial Fenestration.

IJU case reports·2026
Same author

Circulating tumor-associated autoantibody signatures for diagnosis and prognosis in small-cell lung cancer and lung adenocarcinoma.

British journal of cancer·2026
Same author

Adrenal Primary Ganglioneuroblastoma Presenting in Adulthood: A Case Report.

IJU case reports·2026
Same author

Machine Learning Reveals the Contribution of Rare Genetic Variants and Enhances Risk Prediction for Coronary Artery Disease in the Japanese Population.

Circulation. Genomic and precision medicine·2026
Same author

The Biobank Rare Variant consortium powers the discovery of rare genetic associations through global collaboration.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Jun 23, 2025

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

2.9K

KEAP1-NRF2 system regulates age-related spermatogenesis dysfunction.

Sohei Kuribayashi1, Shinichiro Fukuhara1, Hiroaki Kitakaze1

  • 1Department of Urology Osaka University Graduate School of Medicine Suita Japan.

Reproductive Medicine and Biology
|June 25, 2024
PubMed
Summary
This summary is machine-generated.

Aging increases male infertility risk. This study links the KEAP1-NRF2 oxidative stress system to age-related declines in sperm production and function, offering potential therapeutic targets.

Keywords:
KEAP1–NRF2agingmale infertilityoxidative stress

More Related Videos

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

6.1K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.1K

Related Experiment Videos

Last Updated: Jun 23, 2025

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

2.9K
Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

6.1K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.1K

Area of Science:

  • Reproductive biology
  • Molecular mechanisms of aging
  • Oxidative stress research

Background:

  • Increasing paternal age is a global trend.
  • Advanced paternal age is linked to male infertility.
  • The specific molecular pathways affected by aging in spermatogenesis are not fully understood.

Purpose of the Study:

  • To investigate the role of the KEAP1-NRF2 oxidative stress pathway in age-related changes in spermatogenesis.
  • To explore the relationship between aging, oxidative stress, and male fertility.

Main Methods:

  • Comparative analysis of sperm count, motility, and protein expression in mice of different ages (10-90 weeks).
  • Assessment of KEAP1 inhibition using bardoxolone methyl in aged mice.
  • Whole-exome sequencing in a human cohort with non-obstructive azoospermia.

Main Results:

  • Sperm count significantly declined with age in mice.
  • Elevated oxidative stress and KEAP1 expression were observed in aging testes.
  • KEAP1 inhibition in aged mice improved sperm count.
  • A specific NRF2-associated SNP was more frequent in infertile men.

Conclusions:

  • The KEAP1-NRF2 system plays a crucial role in age-related spermatogenesis dysfunction.
  • Targeting the KEAP1-NRF2 pathway may offer therapeutic strategies for male infertility associated with aging.