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Updated: Jun 23, 2025

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
Published on: April 6, 2022
Endothelial cellular senescence and tau accumulation: An interplay full of opportunities?
Doriana Oliveri1,2, Giorgia Moschetti1,2, Anna Griego1,2
1Department of Pharmaceutical Sciences (DISFARM) University of Milan Milan Italy.
Abstract:
Recent research has shown that tau protein can be passed to neighboring cells, leading to cellular senescence in the endothelial cells present in the central nervous system (CNS). This discovery could potentially open new doors for testing novel therapeutic compounds that specifically target senescent cells (senolytics) or for identifying new biomarkers that can enable early detection of tauopathies and dementia.
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