Related Experiment Video

Updated: Jun 23, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.3K

Impact of Elevated Lipoprotein A on Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention: A

Tanya Sinha1, Manisha Guntha2, Abshiro H Mayow3

  • 1Internal Medicine, Tribhuvan University, Kathmandu, NPL.

Cureus
|June 25, 2024
PubMed

Insights

Elevated Lipoprotein(a) (Lp(a)) levels significantly increase the risk of major adverse cardiovascular events (MACE) and mortality after percutaneous coronary intervention (PCI). Targeting Lp(a) may reduce residual cardiovascular risk in these patients.

Area of Science:

  • Cardiology
  • Genetics
  • Preventive Medicine

Background:

  • Lipoprotein(a) (Lp(a)) is an inherited particle linked to atherosclerotic cardiovascular disease risk.
  • The specific impact of elevated Lp(a) on outcomes following percutaneous coronary intervention (PCI) requires further clarification.

Purpose of the Study:

  • To evaluate the association between elevated Lp(a) levels and major adverse cardiovascular events (MACE) and other outcomes in patients undergoing PCI.
  • To synthesize current evidence on Lp(a) and post-PCI cardiovascular events.

Main Methods:

  • Systematic literature search of Embase, MEDLINE/PubMed, and Web of Science (2015-2024).
  • Inclusion of 15 studies with 45,059 patients comparing outcomes based on Lp(a) levels.
  • Meta-analysis of risk ratios (RRs) using a random-effect model for MACE, mortality, myocardial infarction, stroke, and revascularization.

Main Results:

  • Elevated Lp(a) was significantly associated with a higher risk of MACE (RR 1.38).
  • Increased risks were observed for all-cause mortality (RR 1.26), cardiovascular death (RR 1.58), myocardial infarction (RR 1.44), revascularization (RR 1.38), and stroke (RR 1.18).
  • Considerable heterogeneity was noted for some outcomes.

Conclusions:

  • Elevated Lp(a) levels predict worse cardiovascular outcomes post-PCI.
  • Higher rates of MACE, mortality, and recurrent ischemic events are linked to elevated Lp(a).
  • Therapeutic strategies targeting Lp(a) reduction could mitigate residual cardiovascular risk in this population.

Keywords:
cardiovascular outcomeslipoprotein (a)mortalitypercutaneous coronary interventionsystematic review and meta-analysis

More Related Videos

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

11.1K
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.6K

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
154
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
535
Inflammation01:38

Inflammation

Overview
53.3K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
77