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Related Concept Videos

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

979
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Development of Immunocompetence01:22

Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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Related Experiment Video

Updated: Jun 23, 2025

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
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Synchronized development of thymic eosinophils and thymocytes.

Ayami Ota1, Takahiro Iguchi1, Sachiko Nitta1

  • 1Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

International Immunology
|June 25, 2024
PubMed
Summary

Thymic eosinophils are a unique cell subset regulated by interactions with thymic epithelial cells and developing T cells. T cell differentiation is necessary for their induction, revealing a thymus-specific immune cell population.

Keywords:
double-positive thymocytesmedullary thymic epithelial cellsthymustranscriptome

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • The thymus is crucial for T cell development.
  • Thymus contains abundant eosinophils, but their role is unknown.

Purpose of the Study:

  • Characterize gene expression and differentiation of mouse thymic eosinophils.
  • Investigate the regulation of thymic eosinophils.

Main Methods:

  • Gene expression profiling of thymic eosinophils.
  • Analysis of eosinophil populations in genetically modified mice (Rag-deficient).
  • Assessment of T cell differentiation stages.

Main Results:

  • Thymic eosinophils exhibit a unique gene expression profile.
  • Medullary thymic epithelial cells (mTECs) control eosinophil numbers.
  • T cell differentiation beyond CD4- CD8- stage is required for eosinophil induction.

Conclusions:

  • Thymic eosinophils are quantitatively regulated by mTECs.
  • Developing thymocytes qualitatively regulate thymic eosinophils.
  • Thymic eosinophils represent a distinct, thymus-specific cell subset induced by cellular interactions.