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Sleep disturbance associated with the menopause.
Pauline M Maki1, Nick Panay2, James A Simon3
1From the University of Illinois, Chicago, IL.
Menopause (New York, N.Y.)
|June 25, 2024
Summary
Menopause-related sleep disturbances, marked by awakenings and increased awake time, significantly impact women's health. Understanding the underlying neurobiology offers potential for targeted treatments.
Area of Science:
- Neuroscience
- Reproductive Endocrinology
- Sleep Medicine
Background:
- Sleep disturbance is a prevalent and severe symptom for women during menopause.
- Current therapies are not specifically approved for menopause-associated sleep issues.
- This review explores the characterization, etiology, and impact of menopausal sleep disturbance.
Purpose of the Study:
- To characterize sleep disturbance in menopause.
- To discuss the etiology, including recent advances in neuronal circuits.
- To examine current and future treatment strategies.
Main Methods:
- Literature review.
- Expert discussion in sleep and menopause.
- Clinical practice experience integration.
Main Results:
- Menopausal sleep disturbance involves frequent night awakenings and increased awake time after sleep onset.
- Impacts extend to overall health, relationships, productivity, and work performance.
- Hormonal changes, vasomotor, and mood symptoms contribute to sleep disturbances.
Conclusions:
- There is a significant unmet need for effective and safe treatments for menopausal sleep disturbance.
- Recognition of the link between sleep disturbances and menopause is crucial.
- Understanding estrogen-sensitive neurons (kisspeptin/neurokinin B/dynorphin) in the hypothalamus offers a pathway for targeted therapies by integrating reproductive, thermoregulatory, and sleep-wake pathways.
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