Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interactions between mast cells, fibroblasts and connective tissue components.

F M Atkins, M M Friedman, P V Subba Rao

    International Archives of Allergy and Applied Immunology
    |January 1, 1985
    PubMed
    Summary

    Mast cells release granules that interact with connective tissue. Fibroblasts phagocytose and degrade these granules, influencing tissue components and cell function.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Identification of alpha-gal sensitivity in patients with a diagnosis of idiopathic anaphylaxis.

    Allergy·2017
    Same author

    Occupational Dermatoses Among the Cashew Nut Workers in Karnataka.

    Indian journal of dermatology, venereology and leprology·2017
    Same author

    Proposed diagnostic criteria and classification of basophilic leukemias and related disorders.

    Leukemia·2017
    Same author

    Development and validation of the mastocytosis quality of life questionnaire: MC-QoL.

    Allergy·2016
    Same author

    Seasonal variation in nutritional composition of Kappaphycus alvarezii (Doty) Doty-an edible seaweed.

    Journal of food science and technology·2015
    Same author

    KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis.

    Leukemia·2015

    Area of Science:

    • Cell Biology
    • Histology
    • Immunology

    Background:

    • Mast cells are present in connective tissues and release granules when stimulated.
    • Extracellular granules are observed to be phagocytosed by fibroblasts and phagocytic cells.
    • In vivo observations suggested mast cell granules alter connective tissue and influence fibroblast function.

    Purpose of the Study:

    • To confirm the interaction between mast cells and connective tissue components.
    • To investigate the phagocytosis and degradation of mast cell granules by fibroblasts.

    Main Methods:

    • In vitro studies using cultured fibroblasts.
    • Experiments with isolated mast cells and mast cell granules.
    • Microscopic examination of cellular interactions and granule degradation.

    Related Experiment Videos

    Main Results:

    • In vitro studies confirmed that mast cell granules alter connective tissue components.
    • Fibroblasts were shown to phagocytose mast cell granules.
    • Fibroblasts were documented to degrade ingested mast cell granules.

    Conclusions:

    • Mast cells and connective tissue components engage in critical interactions.
    • Fibroblasts play a role in processing mast cell granules.
    • Mast cell degranulation influences the connective tissue environment.