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Updated: May 13, 2026
07:27
Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
Published on: December 18, 2012
12.0K
Relapsed Mpox Keratitis, St. Louis, Missouri, USA.
Emerging Infectious Diseases
|June 25, 2024
Summary
A man with advanced HIV developed severe mpox keratitis, which initially improved with treatment but relapsed despite negative tests. This severe ocular mpox case ultimately required a corneal transplant.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Virology
Background:
- Human Immunodeficiency Virus (HIV) infection can predispose individuals to opportunistic infections.
- Mpox (formerly monkeypox) is a viral disease that can affect various organs, including the eyes.
Observation:
- A 46-year-old man with newly diagnosed advanced HIV presented with PCR-confirmed mpox keratitis.
- Initial treatment with intravenous tecovirimat and penicillin for suspected ocular syphilis led to resolution of keratitis.
Findings:
- The patient experienced a relapse of ipsilateral, PCR-positive mpox keratitis despite an initial negative PCR result.
- Severe ocular mpox necessitated a corneal transplant, highlighting the potential for aggressive disease progression.
Implications:
- This case underscores the importance of considering mpox in patients with advanced HIV presenting with ocular symptoms.
- Recurrent or severe ocular mpox may require advanced interventions like corneal transplantation.
- Further research is needed to understand the pathogenesis and optimal management of ocular mpox in immunocompromised individuals.
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