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Updated: Jun 23, 2025

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

[Complex cutaneous leishmaniasis with bone involvement].

G A Hübner¹, W Prüßmann², N Jossifov²

¹Klinik für Dermatologie, Allergologie und Venerologie (Hautklinik), UKSH Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland. Gisela.Huebner@uksh.de.

Dermatologie (Heidelberg, Germany)

|June 25, 2024

Summary

This case report details a rare bone infection in an immunocompromised patient caused by Leishmania infantum. Early diagnosis and treatment with miltefosine are crucial for managing cutaneous leishmaniasis with extracutaneous spread.

Keywords:

Immunosuppression Leishmania infantum Pathogen diagnostics Polymerase chain reaction Skin manifestations

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Published on: March 16, 2018

Area of Science:

Infectious Diseases
Parasitology
Dermatology

Background:

Cutaneous leishmaniasis (CL) is a parasitic disease primarily affecting the skin.
Immunocompromised individuals are at higher risk for disseminated and atypical CL presentations.
Leishmania infantum is a known cause of visceral leishmaniasis and can cause CL.

Observation:

A single bone lesion in the little toe of an immunocompromised patient was observed.
The lesion was attributed to Leishmania (L.) infantum infection.
Diagnosis was confirmed via polymerase chain reaction (PCR) on skin and bone tissue.

Findings:

This report documents the first instance of osseous involvement in CL caused by Leishmania infantum.
Polymerase chain reaction (PCR) confirmed Leishmania infantum in both skin and bone tissue.
The patient achieved successful treatment with miltefosine.

Implications:

Extracutaneous manifestations of CL, including bone involvement, must be considered in immunocompromised patients.
This case highlights the importance of thorough investigation for disseminated disease in CL.
Early detection and appropriate treatment are vital for managing complex CL cases.