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Related Concept Videos

Electrospray Ionization (ESI) Mass Spectrometry01:12

Electrospray Ionization (ESI) Mass Spectrometry

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Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...
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Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

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In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
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Chemical Ionization (CI) Mass Spectrometry01:21

Chemical Ionization (CI) Mass Spectrometry

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The molecular ion peak of a molecule in the mass spectrum provides vital information for molecular identification. However, conventional electron impact ionization can lead to the rapid dissociation of some molecular ions before they reach the detector. A milder ionization method is required to increase the lifetime of such ionized analyte molecules. Chemical ionization (CI) is a gas-phase protonation reaction useful for mass-analyzing analyte molecules that are easily protonated to yield the...
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Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle01:19

Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle

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Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
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Atomic Emission Spectroscopy: Lab01:29

Atomic Emission Spectroscopy: Lab

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AES is a powerful analytical technique, especially effective when used with plasma sources, producing abundant spectra in characteristic emission lines. The Inductively Coupled Plasma (ICP), in particular, yields superior quantitative analytical data due to its high stability, low noise, low background, and minimal interferences under optimal experimental conditions. However, newer air-operated microwave sources are emerging as promising alternatives that could be more cost-effective than...
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Capillary Electrophoresis: Instrumentation01:20

Capillary Electrophoresis: Instrumentation

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Capillary electrophoresis instrumentation typically consists of several key components. A high-voltage power supply generates the electric field necessary for the separation by connecting to an anode (the positively charged electrode) and a cathode (the negatively charged electrode) located in buffer reservoirs at each end of the capillary tube. The system includes a sample vial, a fused silica capillary tube coated with polyimide for mechanical strength through which the sample components...
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Updated: Jun 23, 2025

Sample Preparation for Probe Electrospray Ionization Mass Spectrometry
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Electroless Ionization Mass Spectrometry Using a Compact Electrokinetic Ionization Source.

Stefan Kooij1, Aleksandra Chojnacka2, Daniel Bonn1

  • 1Van der Waals-Zeeman Institute, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.

Analytical Chemistry
|June 25, 2024
PubMed
Summary
This summary is machine-generated.

A novel electroless spray ionization (ELI) technique enables portable mass spectrometry without electronics. This self-ionizing method efficiently analyzes low-conductive liquids for on-site applications.

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Instrumentation

Background:

  • Conventional ionization techniques for mass spectrometry often require complex electronics and extensive sample preparation.
  • There is a need for simplified, portable ionization methods suitable for on-site analysis.

Purpose of the Study:

  • To introduce and characterize a new, self-ionizing technique for compact mass spectrometers.
  • To demonstrate the applicability of this technique in ambient mass spectrometry scenarios.

Main Methods:

  • Development of a self-ionizing spray nozzle using a microfabricated chip integrated with a disposable syringe.
  • Characterization of the electroless spray ionization (ELI) technique's performance with various solutions.
  • Application of ELI for on-site perfume fingerprinting and fungicide screening on citrus fruits.

Main Results:

  • The electroless spray ionization (ELI) technique achieves comparable performance to conventional methods.
  • ELI demonstrates superior ionization efficiency for low-conductive solutions like water and acetonitrile.
  • The technique eliminates the need for elaborate cleaning procedures due to disposable components.

Conclusions:

  • Electroless spray ionization (ELI) offers a promising, electronics-free ionization method for portable mass spectrometry.
  • Its compact size and efficiency make it suitable for integration into various analytical systems.
  • ELI shows significant potential for rapid, on-site chemical analysis in diverse fields.