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Interplay between epigenetic mechanisms and transcription factors in atherosclerosis

Misbah Aziz1, Karin Am Jandeleit-Dahm2, Abdul Waheed Khan1

  • 1Department of Diabetes, Central Clinical School, Monash University, Melbourne, Australia.

Atherosclerosis
|June 25, 2024
PubMed

Insights

Atherosclerosis, a key factor in cardiovascular diseases (CVD), involves gene regulation by transcription factors and epigenetics. Understanding their crosstalk offers novel therapeutic strategies for CVD.

Area of Science:

  • Cardiovascular Science
  • Molecular Biology
  • Genetics

Background:

  • Cardiovascular diseases (CVD) are the leading global cause of mortality.
  • Atherosclerosis, a vascular inflammatory disease, is a major contributor to CVD.
  • Gene expression regulation by transcription factors and epigenetic mechanisms is crucial in atherosclerosis development.

Purpose of the Study:

  • To review the underappreciated crosstalk between transcription factors and epigenetic mechanisms in atherosclerosis.
  • To highlight novel therapeutic strategies targeting these mechanisms for CVD treatment.

Main Methods:

  • Literature review of studies on gene regulation in atherosclerosis.
  • Analysis of the interaction between transcription factors and epigenetic modifiers.
  • Exploration of potential therapeutic targets in atherosclerotic CVD.

Main Results:

  • Transcription factors and epigenetic mechanisms play fundamental roles in atherosclerosis.
  • Crosstalk between these factors is critical but understudied in CVD.
  • Chromatin remodeling offers potential therapeutic avenues for CVD.

Conclusions:

  • Understanding the interplay between transcription factors and epigenetics is key to developing novel CVD therapeutics.
  • Targeting epigenetic modifiers and transcription factors holds promise for combating atherosclerotic CVD.

Keywords:
AtherosclerosisCardiovascular diseasesChromatin remodelingEpigenetic modifiersEpigeneticsTranscription factor

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