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Updated: Jun 23, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

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RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer

Cameron P Bracken1, Gregory J Goodall1, Philip A Gregory2

  • 1Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA 5000, Australia; Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA 5000, Australia; School of Biological Sciences, Faculty of Sciences, Engineering and Technology, The University of Adelaide, Adelaide, SA 5000, Australia.

Seminars in Cancer Biology
|June 25, 2024
PubMed

Insights

Non-coding RNAs regulate epithelial-mesenchymal transition (EMT) and TGF-β signaling, crucial for cancer metastasis. This review details the roles of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) in these processes.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • Epithelial-mesenchymal transition (EMT) drives cancer metastasis and is regulated by TGF-β signaling.
  • Non-coding RNAs, including miRNAs, lncRNAs, and circRNAs, are key regulators of gene expression.
  • The miR-200 family's role in the EMT-TGF-β axis is well-established, but lncRNA and circRNA functions are emerging.

Purpose of the Study:

  • To review the current understanding of non-coding RNAs in EMT and TGF-β signaling.
  • To highlight the impact of these non-coding RNAs on cancer progression.
  • To synthesize the roles of miRNAs, lncRNAs, and circRNAs in regulating these critical cellular processes.

Main Methods:

  • Literature review of studies on non-coding RNAs, EMT, and TGF-β signaling.
  • Analysis of research focusing on the regulatory mechanisms of non-coding RNAs.
  • Synthesis of findings related to cancer progression and non-coding RNA involvement.

Main Results:

  • MicroRNAs, particularly the miR-200 family, are critical regulators of the EMT-TGF-β feedback loop.
  • Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) also play significant roles in modulating EMT and TGF-β signaling.
  • These non-coding RNAs collectively influence gene expression, impacting cellular states and cancer progression.

Conclusions:

  • Non-coding RNAs are integral to the regulation of EMT and TGF-β signaling pathways.
  • Understanding the multifaceted roles of miRNAs, lncRNAs, and circRNAs is crucial for deciphering cancer metastasis.
  • Further research into these non-coding RNAs offers potential therapeutic strategies for cancer treatment.
Keywords:
CircRNAEMTLncRNAMiR-200MiRNATGF-β

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