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Intriguing connection between diminished ovarian reserve and childhood traumatic experiences, a prospective
Reyhan Çanakci1, Yeşim Uncu2, Kiper Aslan3
1Department of Family Medicine and Palliative Care, Mudanya State Hospital, Bursa, Turkey.
Journal of Gynecology Obstetrics and Human Reproduction
|June 25, 2024
Summary
Adverse childhood experiences may impact diminished ovarian reserve (DOR). Women with DOR reported higher childhood trauma scores than controls, suggesting a potential link between early life adversity and ovarian reserve.
Area of Science:
- Reproductive Endocrinology
- Psychoneuroendocrinology
- Women's Health
Background:
- Diminished ovarian reserve (DOR) is a significant factor in infertility, traditionally linked to age and genetics.
- The impact of adverse childhood experiences (ACEs) on ovarian reserve remains under-researched.
- Understanding novel risk factors is crucial for advancing infertility treatment and reproductive health.
Purpose of the Study:
- To investigate the association between adverse childhood experiences and diminished ovarian reserve.
- To explore the potential role of psychological factors, such as anxiety and depression, in DOR.
- To identify previously unrecognized risk factors contributing to diminished ovarian reserve.
Main Methods:
- A case-control study was conducted at an Assisted Reproductive Technology (ART) Center.
- 102 infertile women with DOR (case group) and 103 women with male-factor infertility (control group) were enrolled.
- Data on ACEs were collected using the Childhood Trauma Questionnaire (CTQ), and anxiety/depression were assessed using the Hospital Anxiety and Depression Scale (HADS).
Main Results:
- The case group exhibited significantly higher total CTQ scores (38.28 ± 9.86) compared to the control group (35.10 ± 9.52).
- All subscale scores of the CTQ were also elevated in the DOR group.
- While not statistically detailed in the abstract, HADS scores were higher in the case group (15.92 ± 7.98) than controls (14.22 ± 6.87).
Conclusions:
- This study suggests a potential link between adverse childhood experiences and diminished ovarian reserve.
- Elevated childhood trauma scores in women with DOR warrant further investigation into this under-explored risk factor.
- Findings highlight the importance of considering psychological and early life factors in the etiology of infertility.
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