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Pediatric skull inflammatory myofibroblastic tumor: a rare case report and literature review
Eeshan Khurana1, Shaan Mody2, Tanisha Shah2
1NJ Craniofacial Center, Morristown, NJ, 07960, USA. eekmd10@gmail.com.
Abstract:
Inflammatory myofibroblastic tumors (IMTs) represent rare neoplasms, particularly infrequent in the pediatric skull. We present a novel case of a newborn male with a 5 cm right temporal mass and discuss current diagnostic and treatment options for IMTs. A multidisciplinary effort to surgically remove the lesion was successful, and the patient's skull defect healed without neurological deficits. The etiology of IMTs remains elusive, with proposed associations with chromosomal mutations in the anaplastic lymphoma kinase (ALK) gene. Surgical excision remains the primary treatment for IMTs. Promising pharmacological treatments, like Crizotinib, warrant further research into understanding potential alternatives in IMT management.
Insights
This case study highlights a rare pediatric skull tumor, inflammatory myofibroblastic tumor (IMT). Successful surgical removal in a newborn demonstrates effective treatment for this uncommon neoplasm.
Area of Science:
- Pediatric Oncology
- Neurosurgery
- Pathology
Background:
- Inflammatory myofibroblastic tumors (IMTs) are rare neoplasms, with cranial presentations being exceptionally infrequent in pediatric populations.
- Understanding the etiology of IMTs, including potential associations with anaplastic lymphoma kinase (ALK) gene mutations, is crucial for diagnosis and treatment.
- This study focuses on a unique case of IMT in a newborn's skull.
Observation:
- A newborn male presented with a significant 5 cm right temporal mass.
- The mass was surgically excised through a multidisciplinary approach.
- Post-operative recovery was successful, with complete healing of the skull defect and no neurological deficits.
Findings:
- Complete surgical resection is the primary and effective treatment modality for pediatric skull IMTs.
- The successful management of this case underscores the viability of surgical intervention for large cranial IMTs in neonates.
- The patient experienced a favorable outcome with no residual neurological impairment.
Implications:
- This case contributes to the limited literature on pediatric cranial IMTs, offering insights into management strategies.
- Further research into the role of ALK mutations and targeted therapies like Crizotinib is warranted for non-surgical or adjuvant treatment options.
- The findings support the current standard of care, emphasizing surgical excision while opening avenues for future pharmacological investigations in IMT management.
