Survival after Surgery among Cholangiocarcinoma Patients Comparing between Mucin Producing and Non-Mucin Producing

Hathaiwan Moungthard ¹, Kavin Thinkhamrop ^2,3,4,5, Attapol Titapun ^2,3,6

⁰Epidemiology and Biostatistics Program, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.

Asian Pacific Journal of Cancer Prevention : Apjcp +

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June 25, 2024

View abstract on PubMed

Summary

Mucin-producing cholangiocarcinoma (MPCC) patients demonstrate significantly longer survival times and higher survival rates compared to non-MPCC patients. This finding supports MPCC as a distinct prognostic classification for cholangiocarcinoma (CCA).

Area Of Science

Oncology
Gastroenterology
Pathology

Background

Mucin-producing cholangiocarcinoma (MPCC) is a rare subtype of biliary tract cancer.
Limited data exists on the survival outcomes for MPCC.
Understanding MPCC's impact on survival is crucial for patient management.

Purpose Of The Study

To evaluate survival rates and median survival time post-surgery for cholangiocarcinoma (CCA) patients.
To determine the association between MPCC and patient survival outcomes.

Main Methods

Retrospective analysis of 1,249 CCA patients who underwent surgery between 2013-2020.
MPCC classification based on post-surgical pathological findings.
Survival data verified via medical records and civil registration; analyzed using Cox regression.

Main Results

Overall 5-year survival rate for CCA was 28.29%; median survival was 21.77 months.
MPCC patients (16.81% of cohort) had a 5-year survival rate of 44.69% and median survival of 41.21 months.
MPCC was associated with a 35% reduced mortality risk (AHR=0.65).

Conclusions

CCA patients with MPCC exhibit significantly better survival rates and longer survival times than non-MPCC patients.
MPCC represents a valuable prognostic indicator in cholangiocarcinoma.
This classification can inform the development of tailored treatment guidelines for CCA.

Keywords:

CASCAP Mucin-producing Thailand cholangiocarcinoma survival