The advanced lung cancer inflammation index is associated with mortality in peritoneal dialysis patients
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View abstract on PubMed
Summary
This summary is machine-generated.A lower advanced lung cancer inflammation index (ALI) is linked to increased mortality in peritoneal dialysis (PD) patients. This index shows promise as an effective tool for predicting patient outcomes and survival rates.
Area Of Science
- Nephrology
- Inflammation markers
- Prognostic indicators
Background
- Peritoneal dialysis (PD) is associated with high morbidity and mortality rates.
- Systemic chronic low-grade inflammation is a key feature in PD patients.
- The advanced lung cancer inflammation index (ALI) is linked to cancer prognosis.
Purpose Of The Study
- To investigate the relationship between ALI and mortality in PD patients.
- To determine if ALI can predict all-cause and cardiovascular disease (CVD) mortality.
- To assess ALI's predictive value compared to other biomarkers.
Main Methods
- 277 PD patients were recruited and followed up for mortality outcomes.
- Patients were stratified into high-ALI and low-ALI groups based on the median ALI.
- Kaplan-Meier curves, Cox regression, and ROC curves were used for analysis.
Main Results
- Lower cumulative and cardiovascular survival rates were observed in the low-ALI group.
- A lower ALI was an independent risk factor for increased all-cause and CVD mortality (HRs > 1.9 and 2.6, respectively).
- ALI demonstrated superior predictive value for all-cause mortality compared to albumin, BMI, and neutrophil-to-lymphocyte ratio.
Conclusions
- A lower advanced lung cancer inflammation index (ALI) is an independent risk factor for mortality in PD patients.
- ALI shows potential as an effective prognostic indicator for PD patients.
- Further research may validate ALI for routine clinical use in PD management.
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