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Simultaneous Isolation and Culture of Atrial Myocytes, Ventricular Myocytes, and Non-Myocytes from an Adult Mouse Heart
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Cardiac ageing: from hallmarks to therapeutic opportunities

Margaret H Hastings1, Qiulian Zhou1, Chao Wu1

  • 1Stanley and Judith Frankel Institute for Heart and Brain Health, University of Michigan Medical Center, Department of Internal Medicine, North Campus Research Complex, 2800 Plymouth Rd, NCRC Building 25, Ann Arbor, MI 48109-2800, USA.

Cardiovascular Research
|June 25, 2024
PubMed

Insights

Cardiac aging involves structural and functional changes, impacting heart health, especially in older adults. Exercise shows promise in mitigating these effects and improving cardiac function.

Area of Science:

  • Cardiology
  • Gerontology
  • Molecular Biology

Background:

  • Cardiac aging is a complex process with significant public health implications due to global aging populations.
  • Heart failure with preserved ejection fraction (HFpEF) is a growing concern in aging individuals.
  • Understanding the molecular basis of cardiac aging is crucial for developing effective interventions.

Purpose of the Study:

  • To review the structural, cellular, and functional changes in the aging heart.
  • To explore molecular mediators of cardiac aging within the context of aging hallmarks.
  • To discuss the differential effects of aging on cardiac health in men and women, and the role of exercise.

Main Methods:

  • Literature review of structural, cellular, and functional changes in cardiac aging.
  • Analysis of molecular mediators and their relation to aging hallmarks.
  • Examination of sex-specific differences and the impact of exercise on cardiac aging and HFpEF.

Main Results:

  • Cardiac aging involves multifaceted changes affecting structure, cellular processes, and function.
  • Key molecular mediators are linked to established hallmarks of aging, with potential therapeutic targets identified.
  • Significant differences exist in cardiac aging between sexes, influenced by hormones and chromosomes; exercise demonstrates protective effects.

Conclusions:

  • Cardiac aging is a complex process requiring further research to enhance cardiac health in aging populations.
  • Identifying pathways that mitigate biological aging is essential for preventing and treating age-related cardiac conditions like HFpEF.
  • Therapeutic strategies targeting molecular mediators and leveraging lifestyle interventions like exercise are promising for improving cardiovascular outcomes in the elderly.

Keywords:
Cardiac ageingGeroscienceHeart failure

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