Related Experiment Video
Updated: Jun 23, 2025
08:38
Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
16.9K
Acneiform Eruptions Possibly Triggered by Clarithromycin During Sirolimus Treatment
Koki Kataoka1, Saeko Nakajima1,2, Takashi Nomura1,3
1Dermatology, Kyoto University Graduate School of Medicine, Kyoto, JPN.
Cureus
|June 26, 2024
Summary
Acneiform eruptions, a side effect of sirolimus (an mTOR inhibitor), may worsen with clarithromycin due to drug interactions. This interaction can elevate sirolimus levels, potentially triggering or worsening skin reactions.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Sirolimus, an mTOR inhibitor, is known to cause acneiform eruptions.
- The exact mechanisms and dose-dependency of this side effect are not fully understood.
Observation:
- A case report details a 40-year-old woman experiencing acneiform eruptions after starting clarithromycin during sirolimus treatment.
- The eruption resolved upon sirolimus cessation and recurred upon its reintroduction.
Findings:
- Drug interaction between sirolimus and clarithromycin, mediated by cytochrome P450 3A (CYP3A), is suspected.
- This interaction likely led to increased sirolimus blood levels, contributing to the acneiform eruption.
Implications:
- Clinicians should monitor for acneiform eruptions in patients taking sirolimus, particularly when co-prescribed CYP3A inhibitors like clarithromycin.
- Awareness of this potential drug-drug interaction is crucial for managing sirolimus therapy and its dermatological side effects.
Related Concept Videos
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
156
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
156
01:29Pulmonary Tuberculosis I
231
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
231
01:29Drugs for Treatment of Ulcerative Colitis in IBD
134
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
134
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
115
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
115