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Updated: Jun 23, 2025

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
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Disseminated Cutaneous Mucormycosis Developing in Peristomal Pyoderma Gangrenosum.

David A Prentice1,2, Erasmia Christou3,4, Wendy A Pearson5,6

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|June 26, 2024
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Summary
This summary is machine-generated.

Long-term glucocorticoid therapy for peristomal pyoderma gangrenosum (PPG) can lead to invasive mucormycosis (MM). Early skin biopsy and clinical evaluation are crucial for diagnosing and managing resistant PPG cases.

Keywords:
angioinvasivebiopsyfat necrosislipasemucormycosisperistomal pyoderma gangrenosumrhizopus

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Area of Science:

  • Dermatology
  • Mycology
  • Infectious Diseases

Background:

  • Peristomal pyoderma gangrenosum (PPG) is a chronic inflammatory skin condition often managed with immunosuppressants.
  • Long-term glucocorticoid therapy is a common treatment for PPG, but carries risks of opportunistic infections.
  • Invasive fungal infections, such as mucormycosis (MM), are rare but serious complications associated with immunosuppression.

Observation:

  • A case presentation of a patient with PPG on long-term glucocorticoid therapy who developed disseminated mucormycosis.
  • The patient exhibited wound dissemination of mucormycosis, indicating a severe and invasive presentation.
  • This case highlights a critical adverse event associated with the management of PPG.

Findings:

  • The study emphasizes the importance of skin biopsy for diagnosing PPG, especially in cases resistant to conventional therapy or with new symptoms.
  • Clinical evaluation alongside diagnostic procedures is vital for accurate and timely diagnosis.
  • Long-term corticosteroid use significantly increases the risk of invasive fungal infections like mucormycosis.

Implications:

  • Early detection and prompt management of mucormycosis in patients with PPG are critical for improving patient outcomes.
  • Healthcare providers should be vigilant for signs of invasive fungal infections in patients on long-term glucocorticoid therapy.
  • This case underscores the need for careful risk-benefit assessment when prescribing long-term immunosuppression for chronic dermatological conditions.