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Related Concept Videos

Nucleic Acid Structure01:25

Nucleic Acid Structure

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
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Nucleic Acids02:43

Nucleic Acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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RNA Interference01:23

RNA Interference

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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RNA Structure01:19

RNA Structure

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The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
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Nucleic acids02:43

Nucleic acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Updated: Jun 23, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami
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Folding and Characterization of a Bio-responsive Robot from DNA Origami

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DNA-based nanostructures for RNA delivery.

Yuanyuan Wu1, Liangzhi Luo2, Ziyang Hao2

  • 1Beijing SupraCirc Biotechnology Co., Ltd, Beijing, China.

Medical Review (2021)
|June 26, 2024
PubMed
Summary
This summary is machine-generated.

DNA nanotechnology provides a novel solution for delivering RNA therapeutics, overcoming challenges like degradation and poor uptake. This review explores DNA origami, frame-guided assembly lipid nanoparticles, and DNA hydrogels for effective RNA delivery.

Keywords:
DNA hydrogelDNA origamiRNA deliveryframe guided assembly (FGA)gene therapy; DNA-based nanostructures

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Area of Science:

  • Biotechnology
  • Nanotechnology
  • Molecular Biology

Background:

  • RNA therapeutics show promise for treating diseases like cancer and genetic disorders.
  • Delivering RNA into cells is challenging due to degradation and inefficient uptake.
  • DNA nanotechnology offers a programmable and biocompatible platform for RNA delivery.

Purpose of the Study:

  • To review advancements in DNA nanostructures for RNA therapeutic delivery.
  • To highlight the applications of DNA origami, FGA-LNPs, and DNA hydrogels.
  • To discuss challenges and future directions in DNA-based RNA delivery.

Main Methods:

  • Review of current literature on DNA nanostructures for RNA delivery.
  • Focus on DNA origami, frame-guided assembly (FGA) lipid nanoparticles (LNPs), and DNA hydrogels.
  • Discussion of design principles and assembly strategies for these nanostructures.

Main Results:

  • DNA nanostructures offer programmability and biocompatibility for protecting and delivering RNA.
  • DNA origami, FGA-LNPs, and DNA hydrogels are effective platforms for RNA delivery.
  • These nanostructures demonstrate potential in various biomedical applications.

Conclusions:

  • DNA nanotechnology presents a viable strategy to overcome RNA delivery challenges.
  • Further research into DNA nanostructures can advance RNA-based therapeutics.
  • Continued development is needed to address challenges and optimize applications.