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  11. Non-invasive Intracranial Pressure Monitoring For High-grade Gliomas Patients Treated With Radiotherapy: Results Of The Gmapic Trial

Non-invasive intracranial pressure monitoring for high-grade gliomas patients treated with radiotherapy: results of the GMaPIC trial

Mélanie Casile1,2,3, Emilie Thivat1,2,3, Fabrice Giraudet4

  • 1INSERM U1240 IMoST, University of Clermont Auvergne, Clermont-Ferrand, France.

Frontiers in Oncology
|June 26, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

A non-invasive method using otoacoustic emissions can estimate intracranial pressure changes in high-grade glioma patients after radiotherapy. This method correlates with tumor volume changes, offering a potential tool for monitoring cerebral edema.

Area of Science:

  • Neuro-oncology
  • Medical imaging
  • Ophthalmology

Background:

  • High-grade gliomas can cause increased intracranial hypertension (ICHT) due to tumor volume increase.
  • Invasive ICP monitoring is not feasible; estimation relies on clinical signs and MRI.
  • Cerebral edema is a significant side effect of radiotherapy for gliomas, necessitating ICP monitoring.

Purpose of the Study:

  • To compare intracranial pressure (ICP) changes estimated by a non-invasive otoacoustic emissions method with MRI-observed volume changes in glioma patients post-radiotherapy.
  • To evaluate the feasibility of using distortion product otoacoustic emissions (DPOAE) for non-invasive ICP monitoring in high-grade glioma patients.

Main Methods:

  • Prospective clinical study involving high-grade glioma patients treated with radiotherapy.
Keywords:
brain tumorgliomaintracranial pressuremonitoring tool

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  • Non-invasive ICP estimation using distortion product otoacoustic emissions (DPOAE) monitoring.
  • Regular MRI scans and clinical evaluations were performed alongside DPOAE measurements for one year post-radiotherapy.

    • Main Results:

    • A significant association was found between variations in estimated ICP (DPOAE readout) and T2/FLAIR tumor/edema volume changes (p<0.001).
    • A cutoff value of 40.2 degrees in ICP readout change corresponded to an estimated 16 mm Hg change in ICP.
    • The study included 125 patients, demonstrating the reliability of the non-invasive method.

    Conclusions:

    • The GMaPIC trial confirms that non-invasive ICP estimation via DPOAEs correlates with tumor or edema volume changes in high-grade gliomas after radiotherapy.
    • This non-invasive device shows potential as an easy-to-use tool for monitoring intracranial pressure in these patients.
    • Further validation could establish DPOAEs as a standard non-invasive ICP monitoring technique for glioma patients.
    non-invasive
    otoacoustic emissions