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Related Experiment Video

Updated: Jun 23, 2025

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

Published on: April 11, 2014

Plasma Ascorbic Acid Levels in Critically Ill Pediatric Patients.

Daniel Horim Choi¹, Sonali Basu¹, Mark Levine²

¹Department of Pediatrics, Division of Critical Care Medicine, Children's National Hospital, George Washington School of Medicine and Health Sciences, Washington, District of Columbia, United Sates.

Journal of Pediatric Intensive Care

|June 26, 2024

Summary

This summary is machine-generated.

Critically ill children with septic shock or respiratory failure often have low ascorbic acid (vitamin C) levels. Half of the patients studied had deficient levels, highlighting a potential area for nutritional intervention.

Keywords:

PICU ascorbic acid enteral nutrition

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Published on: January 16, 2019

Area of Science:

Pediatric Intensive Care
Nutritional Biochemistry
Critical Care Medicine

Background:

Ascorbic acid (vitamin C) is a vital antioxidant.
Deficiency is noted in critically ill adults with sepsis and ARDS.
Supplementation in adults may reduce vasopressor and ventilation needs.

Purpose of the Study:

To determine the prevalence of ascorbic acid deficiency in critically ill pediatric patients.
To analyze plasma ascorbic acid levels in children with septic shock and/or respiratory failure.

Main Methods:

Prospective, single-centered study of 34 pediatric patients (1 month-18 years).
Patients had septic shock and/or respiratory failure requiring mechanical ventilation.
Plasma ascorbic acid measured via HPLC within 24 hours of eligibility.

Main Results:

Median ascorbic acid level was 23.34 µM; 50% had deficient levels.
Repeat samples 3-5 days later showed higher median levels (42.41 µM).
Enterally fed patients had significantly higher levels than non-fed patients (p=0.03).

Conclusions:

Ascorbic acid levels vary widely in critically ill children.
Half of the studied pediatric patients exhibited deficient levels, similar to scurvy.
Further research is needed on the clinical significance of low levels and benefits of normalization.