Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

260
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
260
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

428
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
428
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

386
Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
386
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

248
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
248
Drug Toxicity: Dose-Dependent Reactions01:24

Drug Toxicity: Dose-Dependent Reactions

245
Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
245
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

118
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
118

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Population-specific Urinalysis Parameters Are Necessary to Improve Diagnostic Value for Urinary Tract Infection.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2024
Same author

Reprint of: Impact of an HIV pre-exposure prophylaxis dashboard on veteran PrEP enrollment.

Journal of the American Pharmacists Association : JAPhA·2024
Same author

Impact of an HIV pre-exposure prophylaxis dashboard on veteran PrEP enrollment.

Journal of the American Pharmacists Association : JAPhA·2024
Same author

Lack of correlation between standardized antimicrobial administration ratios (SAARs) and healthcare-facility-onset <i>Clostridioides difficile</i> infection rates in Veterans Affairs medical facilities.

Infection control and hospital epidemiology·2022
Same author

Incorporation of Clinical Staff Pharmacists in the Emergency Department Sepsis Response at a Single Institution.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS·2022
Same author

Implementing a postdischarge methicillin-resistant <i>Staphylococcus aureus</i> decolonization protocol within a Veterans Affairs Health Care System facility.

Infection control and hospital epidemiology·2021

Related Experiment Video

Updated: May 5, 2026

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
12:17

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Published on: March 17, 2008

15.5K

Case Report: Cefepime Induced Neurotoxicity Following a Change in Infusion Time.

Kendall Stratton1, Kelly W Davis1

  • 1Lexington VA Health Care System, Lexington, KY, USA.

Hospital Pharmacy
|June 26, 2024
PubMed
Summary

Shortened cefepime infusion times may cause neurotoxicity (CIN) even with normal renal function. This case highlights risks during care transitions, suggesting therapeutic drug monitoring for cefepime safety.

Keywords:
adverse drug reactionsinfectious diseasesintravenous therapymonitoring drug therapyneurology

More Related Videos

Functional Evaluation of Biological Neurotoxins in Networked Cultures of Stem Cell-derived Central Nervous System Neurons
15:05

Functional Evaluation of Biological Neurotoxins in Networked Cultures of Stem Cell-derived Central Nervous System Neurons

Published on: February 5, 2015

9.4K
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

12.5K

Related Experiment Videos

Last Updated: May 5, 2026

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
12:17

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Published on: March 17, 2008

15.5K
Functional Evaluation of Biological Neurotoxins in Networked Cultures of Stem Cell-derived Central Nervous System Neurons
15:05

Functional Evaluation of Biological Neurotoxins in Networked Cultures of Stem Cell-derived Central Nervous System Neurons

Published on: February 5, 2015

9.4K
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

12.5K

Area of Science:

  • Pharmacology
  • Neuroscience
  • Infectious Diseases

Background:

  • Cefepime is a fourth-generation cephalosporin antibiotic with a known risk of neurotoxicity (CIN).
  • CIN is typically associated with impaired renal function or incorrect cefepime dosing.
  • This report focuses on a novel association between shortened cefepime infusion duration and neurotoxicity.

Observation:

  • A 73-year-old male experienced neurological symptoms within one day of switching to a 30-minute cefepime infusion.
  • These symptoms worsened, necessitating hospital readmission.
  • The patient's renal function remained stable throughout the treatment period.

Findings:

  • Cefepime discontinuation led to complete resolution of neurotoxic symptoms within 48 hours.
  • This case presents cefepime-induced neurotoxicity (CIN) linked to a reduced infusion duration (30 minutes) from a previous 180-minute infusion.
  • No alternative causes for the neurotoxicity were identified.

Implications:

  • Shortened cefepime infusion times represent a potential risk factor for CIN, independent of renal function.
  • This finding is particularly relevant during transitions of care, such as from inpatient to outpatient parenteral antimicrobial therapy (OPAT).
  • Further research and therapeutic drug monitoring are recommended to understand the cefepime infusion time-CIN relationship.