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Muscle Recovery and Fatigue

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...

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Updated: Jun 23, 2025

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

Early poststroke clinically significant fatigue predicts functional independence: a prospective longitudinal study.

Alan Juárez-Belaúnde¹, Vanesa Soto-León², Michele Dileone^3,4

¹Advanced Neurorehabilitation Unit, Hospital Los Madroños, Madrid, Spain.

Frontiers in Neurology

|June 26, 2024

Summary

Early poststroke fatigue predicts poorer functional recovery and quality of life. Managing fatigue, especially in the subacute phase, is crucial for stroke survivors, with differing patterns observed between ischemic and hemorrhagic strokes.

Keywords:

FSS NIHSS fatigue hemorrhagic stroke ischemic stroke outcome

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Area of Science:

Neurology
Rehabilitation Medicine
Clinical Research

Background:

Poststroke fatigue is a common and debilitating condition affecting stroke survivors' recovery and quality of life.
Understanding the relationship between fatigue and functional outcomes is critical for effective patient management.

Purpose of the Study:

To investigate the association between poststroke fatigue and functional recovery in ischemic and hemorrhagic stroke survivors.
To analyze the temporal progression of poststroke fatigue in different stroke subtypes.

Main Methods:

Prospective cohort study of 79 acute stroke patients (ischemic and hemorrhagic).
Fatigue assessed using Fatigue Severity Scale (FSS) and Numeric Rating Scale (NRS_fatigue).
Functional status evaluated with NIH Stroke Scale (NIHSS), Barthel Index (BIADL), and Modified Rankin Scale (MRS).

Main Results:

Early clinically significant fatigue (CSF) predicts poorer functional independence trajectories.
Fatigue ameliorates with functional recovery in hemorrhagic strokes but remains stable in ischemic strokes.
Distinct fatigue progression patterns observed between ischemic and hemorrhagic stroke subtypes.

Conclusions:

Early poststroke fatigue significantly impacts long-term functional outcomes.
Proactive management of poststroke fatigue is essential during the subacute recovery phase.
Tailoring fatigue management strategies based on stroke type may improve patient outcomes.