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Updated: Jun 23, 2025

Reporter-based Growth Assay for Systematic Analysis of Protein Degradation
Published on: November 6, 2014
Systems and Methods for Transformation and Degradation Analysis
Jude A Osara1, Michael D Bryant2,3
1Surface Technology and Tribology, Department of Mechanics of Solids, Surfaces and Systems, University of Twente, 7522 NB Enschede, The Netherlands.
Abstract:
Modern concepts in irreversible thermodynamics are applied to system transformation and degradation analyses. Phenomenological entropy generation (PEG) theorem is combined with the Degradation-Entropy Generation (DEG) theorem for instantaneous multi-disciplinary, multi-scale, multi-component system characterization. A transformation-PEG theorem and space materialize with system and process defining elements and dimensions. The near-100% accurate, consistent results and features in recent publications demonstrating and applying the new TPEG methods to frictional wear, grease aging, electrochemical power system cycling-including lithium-ion battery thermal runaway-metal fatigue loading and pump flow are collated herein, demonstrating the practicality of the new and universal PEG theorem and the predictive power of models that combine and utilize both theorems. The methodology is useful for design, analysis, prognostics, diagnostics, maintenance and optimization.
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