Gene Regulatory Mechanism of Mycobacterium Tuberculosis during Dormancy
Yiduo Liu1,2, Han Li1, Dejia Dai1
1College of Animal Science and Technology, Guangxi University, No. 100 University West Road, Nanning 530004, China.
Abstract:
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) complex, is a zoonotic disease that remains one of the leading causes of death worldwide. Latent tuberculosis infection reactivation is a challenging obstacle to eradicating TB globally. Understanding the gene regulatory network of Mtb during dormancy is important. This review discusses up-to-date information about TB gene regulatory networks during dormancy, focusing on the regulation of lipid and energy metabolism, dormancy survival regulator (DosR), White B-like (Wbl) family, Toxin-Antitoxin (TA) systems, sigma factors, and MprAB. We outline the progress in vaccine and drug development associated with Mtb dormancy.
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