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Sexually Transmitted Infections

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Updated: Jun 23, 2025

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Early neurosyphilis with serofast state.

Souheil Zayet¹, Samantha Poloni¹, Vincent Gendrin¹

¹Infectious Diseases Department, Nord Franche-Comté Hospital, Trevenans, France.

Emerging Microbes & Infections

|June 26, 2024

Summary

This case study details a rare instance of early neurosyphilis in an HIV-negative patient with diabetes. Despite treatment, the patient exhibited a serofast state with persistent high syphilis titers.

Area of Science:

Neurology
Infectious Diseases
Immunology

Background:

Neurosyphilis is a serious complication of syphilis affecting the nervous system.

Keywords:

Neurosyphilis cerebrospinal fluid meningitis nontreponemal antibodies serofast

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Early neurosyphilis can present with diverse neurological symptoms.

The serofast state, characterized by persistently elevated non-treponemal antibody titers post-treatment, is not fully understood.