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Updated: Jun 23, 2025

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
Published on: January 24, 2025
Early neurosyphilis with serofast state
Souheil Zayet1, Samantha Poloni1, Vincent Gendrin1
1Infectious Diseases Department, Nord Franche-Comté Hospital, Trevenans, France.
Abstract:
We report a rare case of confirmed early neurosyphilis with serofast state in HIV-negative patient, with uncontrolled type 2 diabetes mellitus. Syphilitic meningitis was diagnosed initially on serology and cerebrospinal fluid (CSF) analysis. The patient had persistently raised non-treponemal titres on serum with negative CSF venereal disease research laboratory result, following treatment during 3 years of follow-up.
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