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Updated: Jun 16, 2026

Immuno-fluorescence Assay of Leptospiral Surface-exposed Proteins
Published on: July 1, 2011
Ocular Leptospirosis: Report of a Challenging Diagnosis
Guilherme Macedo Souza1,2, Heloisa Nascimento1, Rubens Belfort1,2
1Department of Ophthalmology and Visual Science, Federal University of Sao Paulo, Sao Paulo, Brazil.
Purpose:
To report a challenging case of serologically confirmed posterior uveitis due to leptospirosis.
Methods:
Review of medical records.
Results:
Thirteen-year-old boy presented focal necrotizing retinochoroiditis after flood exposure. Laboratory work-up confirmed leptospirosis infection and proper antibiotic treatment was done. The patient evolved well. but during late follow-up he developed nummular keratitis.
Conclusion:
Leptospirosis is a possible etiology of necrotizing posterior uveitis. The use of antimicrobial therapy is controversial but was used in this case, in association with corticosteroids, leading to resolution of retinal inflammation. Despite treatment, the patient developed late corneal opacities, which did not lead to visual impairment.
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